MAPT anticorps (pThr181)

N° du produit ABIN1108152

Cet anticorps anti-MAPT est un anticorps Souris Monoclonal détectant MAPT dans WB. Adapté pour Humain et Souris.

Aperçu rapide pour MAPT anticorps (pThr181) (ABIN1108152)

Antigène: MAPT (Microtubule-Associated Protein tau (MAPT))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MAPT est non-conjugé

Application: Western Blotting (WB)

Clone: 1A4

Détail du produit anti-MAPT anticorps

Épitope: AA 177-187, pThr181

Séquence: Ala-Pro-Lys-Thr(p)-Pro-Pro-Ser-Ser-Gly-Glu-Cys

Réactivité croisée (Details): Species reactivity (tested):Human, mouse

Purification: Protein G affinity purified

Immunogène: KLH conjugated with a short peptide corresponding to the amino acid sequence 177-187 on the phosphorylated Tau protein

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Double distillated water is recommended to reconstitute the antibody.

Buffer: 0.01 M PBS pH 7.2

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.

Détails sur MAPT

Antigène: MAPT (Microtubule-Associated Protein tau (MAPT))

Autre désignation: MAPT / tau

Sujet: Tau is a neuronal microtubule associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerisation and stabilise microtubules, but it also serves to link certain signalling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of Tau, resulting in the destabilisation of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK3 beta, PKA, Cdk5, and casein kinase II can phosphorylate Tau.Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau

ID gène: 9606

UniProt: P10636

Pathways: Signalisation MAPK, Dynamique des Microtubules, M Phase, Regulation of Cell Size